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2024年3月18日 星期一

兒童風濕科的第三隻手:超音波解碼兒童風濕病的隱藏訊息(本文刊登於9月長庚醫訊_兒童醫療)

作者:曾吉騰




筆者記得有一次跟朋友閒聊的時候
當朋友聽到我要幫小朋友做關節超音波時問到:
曾醫師,你們科的關節超音波到底在檢查什麼呢?

確實,肌肉骨骼關節超音波在兒童風濕病的發展
算是近期新興發展的檢查
台灣也很少有兒童風濕科醫師有機會學習
筆者就藉此機會跟大家簡單介紹這項新的技術

關節超音波在風濕科的發展契機


關節超音波的發展其實可以追朔至1990年左右
一開始主要是復健科醫師以及放射科醫師
有感於理學檢查跟傳統的X光檢查
無法協助病人找出骨骼肌肉不適的原因
甚至在做一些侵入性的檢查時會有併發症的風險
因此開始發展一系列超音波的檢查與治療

對於臨床上照顧風濕病的病人
我們可以發現不少比例會抱怨關節不舒服
除了外傷、老化等等因素外
有可能起因於自體免疫疾病攻擊身體組織
導致骨骼肌肉關節受影響產生病痛

一開始病人會輾轉求助於骨科、復健科
但因為反覆發作,或是治療效過不彰
最後才發現是風濕性關節疾病
才被轉到風濕科就醫
但往往已發生了不可逆的傷害

此外,被確診為風濕關節炎的病人
在治療穩定後準備停用免疫調節藥物
卻又復發也造成了病人身心俱疲
照護的醫護人員也因此承擔了不少壓力

因此,關節超音波因應而生
有越來越多的研究顯示超音波
可以幫助這群風濕性關節炎的病人
不論是在診斷疾病追蹤治療上都有很重要的角色

有鑑於成人風濕科引進超音波檢查
大大改善病人的治療
增加了醫病間的溝通
提升了病人用藥的順從性
兒童風濕科醫師也開始發展了超音波

關節超音波檢查在兒科的優點





相較於傳統的X光或是電腦斷層檢查
只能針對是否發生骨折跟關節錯位問題
拜科技進步所賜
超音波對於骨骼韌帶肌肉軟組織可提供更清楚精細的成像及檢查
也因為不具有放射性
一次可以掃描檢查多個關節
即時性、可近性以及方便操作等優點
於是在歐美颳起了一陣旋風

有許多研究也顯示
當臨床理學檢查不確定是否有關節炎時 (特別是深層的關節,如:肩關節、髖關節…)
關節超音波可以提供更客觀的影像跟原因
增進醫師的診斷正確度
以及提升病童及家屬的滿意度~
此外,針對兒童特發性關節炎的關節軟骨病變
也可以偵測到早期結構上的病變(如:滑膜增生、滑膜炎、軟骨變薄…)

這也使得歐洲風濕病學會以及歐洲兒童風濕病學會
開始認可推行關節超音波的使用
以及安排了許許多多的訓練課程
幫助更多的病童獲得更好的照顧


為何需要由兒童過敏氣喘風濕科醫師親自執行超音波檢查?

由兒童過敏氣喘風濕科醫師執行超音波檢查,有下列幾項好處:
1. 對於容易哭鬧不安的兒童,兒科醫師更懂得與其互動和安撫兒童接受檢查時各種哭鬧躁動,提升檢查的成功率和影像的精細度。
2. 兒童風濕科醫師對於骨骼肌肉關節系統的解剖與病生理機轉有更深一層認識,如:生長板、次級骨化中心等等結構可以辨識為正常生理結構,加上能夠綜合臨床症狀與理學檢查的結果,辨識出該檢查是否異常,不僅降低誤診率,也減少家屬不必要的擔憂和緊張。
3. 藉由超音波檢查所提供的訊息,可以讓病童與家屬參與醫病共享決策,提供個人化的治療方針,增加病童藥物服從性。


小結


隨著超音波技術日新月異
更小更精細的探頭推陳出新
甚至有可攜式的超音波機器
只需要手機連藍芽就可以進行超音波檢查

對於兒童關節超音波的研究
也在近年呈現爆炸式的成長
風濕關節炎病童的照顧也因此提升許多

當病童出現以下幾種情形可以考慮超音波檢查(4,6):
1. 反覆不明關節腫痛合併晨僵(morning stiffness)
2. 突發性單關節腫脹、跛行合併發燒 (Limping gait with fever)
3. 高度懷疑敗血性關節炎,需要進行關節液抽吸檢查與減壓 (diagnositc arthrocentesis with decompression)
4. 當臨床理學檢查無法確定是否為關節炎,X光檢查沒有骨折或錯位等原因,欲進一步檢查骨骼肌肉韌帶等軟組織問題

感謝林口長庚兒童過敏氣喘風濕科的先進栽培 (請參考文章:歐洲兒童風濕病學會關節超音波進修)
筆者有幸接觸到此新穎的檢查技術
為廣大的病童提供該檢查服務
歡迎有相關問題的家長來門診詢問(門診時間表如下)




掛號請按我

English Version, with help from Gemini Pro

From Uncertainty to Pricion: Decoding Hidden Clinical Messages via Musculoskeletal Ultrasound

Author: Chi-Teng (Jeter) Tseng, MD (Originally published in Chang Gung Medical News, September Issue – Pediatric)

Few months ago, one of my friend asked me upon hearing that I perform joint ultrasounds on children: "Dr. Tseng, what exactly are you looking for during a pediatric joint ultrasound?"

Indeed, Musculoskeletal Ultrasound (MSUS) is a rapidly emerging diagnostic modality within the field of pediatric rheumatology. In Taiwan, the opportunity to master this specialized technique remains relatively rare. I would like to take this opportunity to introduce this technology and its transformative impact on patient care.


The Evolution of MSKUS in Rheumatology

The development of MSKUS dates back to the early 1990s. Initially pioneered by physiatrists and radiologists, the movement was driven by a shared realization: conventional physical examinations and X-rays often failed to identify the root cause of musculoskeletal discomfort. Furthermore, invasive procedures performed "blindly" carried inherent risks of complications.

In rheumatology, a significant number of patients present with joint pain. Beyond trauma or degenerative aging, these symptoms often stem from autoimmunity against tissues or organs among patients.

Many pediatric patients initially seek help from orthopedic or rehabilitation clinics. Due to the relapsing nature of autoimmune conditions or suboptimal initial treatment, they often undergo a "diagnostic odyssey" before finally being referred to a rheumatologist. Unfortunately, by the time a diagnosis is reached, irreversible joint damage may have already occurred. Moreover, even when a patient is stable, the anxiety surrounding the tapering of immunomodulators—and the subsequent fear of relapse—places immense pressure on both patients and healthcare providers.

Consequently, MSUS has emerged as a vital tool. A growing body of research confirms its indispensable role in the diagnosis, monitoring, and therapeutic adjustment for inflammatory arthritis.


Advantages of Ultrasound in Pediatric Rheumatology

Inspired by the success in adult rheumatology—where ultrasound has improved patient outcomes, enhanced physician-patient communication, and boosted medication adherence—pediatric specialists have begun integrating MSUS into standard care.

Compared to traditional X-rays or CT scans, which primarily identify fractures or dislocations, modern ultrasound provides:

  • High-Resolution Soft Tissue Imaging: Superior visualization of ligaments, muscles, and synovial tissues.

  • Zero Radiation: A critical safety factor for the developing pediatric population.

  • Multi-Joint Assessment at once: The ability to scan multiple sites in a single session.

  • Real-time & Dynamic Capability: Immediate bedside results with the ability to observe joints in motion.

Research indicates that when physical exams are inconclusive—especially in deep-seated joints like the shoulders or hips—MSKUS provides objective evidence that increases diagnostic accuracy and parental satisfaction. It can detect early structural changes, such as synovial hypertrophy, synovitis, and cartilage thinning, long before they appear on an X-ray.


Why Should Pediatric Rheumatologists Perform the Scan Themselves?

Having the treating subspecialist perform the ultrasound offers distinct clinical advantages:

  1. Pediatric Expertise: Pediatricians are uniquely skilled in soothing and interacting with anxious or uncooperative children, which is essential for capturing high-quality, precise images.

  2. Specialized Anatomical Knowledge: Understanding pediatric-specific structures—such as growth plates (physes) and secondary ossification centers—is crucial. A rheumatologist can distinguish these normal physiological markers from pathology, significantly reducing misdiagnosis and unnecessary parental anxiety.

  3. Shared Decision-Making (SDM): By showing parents and patients real-time images of the inflammation, we can involve them in the decision-making process. This visualization fosters a personalized treatment plan and significantly improves patient compliance with long-term medications.


Clinical Indications for Ultrasound

As ultrasound technology advances, with high-frequency probes becoming smaller and even portable (Bluetooth-enabled via smartphone), its application in pediatric care is expanding exponentially.

We strongly consider an MSKUS evaluation for children presenting with:

  1. Recurrent, unexplained joint swelling/pain accompanied by morning stiffness.

  2. Sudden onset of monoarthritis or a limping gait associated with fever.

  3. Suspected septic arthritis, requiring urgent diagnostic arthrocentesis and joint decompression.

  4. Cases where physical exams are ambiguous and X-rays show no fractures, but soft tissue pathology (ligament or muscle issues) is suspected.

Conclusion

While ultrasound does not replace a comprehensive clinical history and physical exam, it serves as a powerful "third hand" for the clinician. It provides the clarity needed to decode the hidden messages within a child's joints, making the physician goes from uncertainty to precision.


參考資料:
1.  J Intern Med Taiwan 2010; 21: 6-11
2.  Pediatric Rheumatology 2011, 9:25
3.  Ann Rheum Dis. 2015 Nov;74(11):1946-57.
4.  Best Practice & Research Clinical Rheumatology 34 (2020) 101570
5.  Current Rheumatology Reports, 14 Apr 2020, 22(5):14
6.  Eur J Rheumatol. 2022;10.5152/eujrheum